Hexima prides itself on publishing quality, cutting-edge science in high-impact, posters and peer-reviewed journals.


POSTER: Presented at The American Podiatric Medical Association (APMA) annual meeting, Denver, Colorado, A phase I/IIa, randomized, double-blind, vehicle-controlled study of pezadeftide (HXP124), a novel topical treatment, in patients with onychomycosis (pdf)


Bleackley Mark, Dawson C, Payne J, Harvey P, Rosengren J, Quimbar P, García-Cerón D,Lowe R, Bulone V, van der Weerden N, Craik D J & Anderson M, The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins. The Cell Surface. 5. 100026. 10.1016/j.tcsw.2019.100026. (2019)


Hayes B, Bleackley M, Anderson MA, van der Weerden N, The plant defensin NaD1 enters the cytoplasm of Candida albicans via endocytosis., J Fungi. (2018)

Parisi K, Shafee TMA, Quimbar P, van der Weerden NL, Bleackley MR, Anderson MA., The evolution, function and mechanisms of action for plant defensins., Seminars in Cell and Developmental Biology (In Press) (2018)

POSTER: Presented at The International Society for Human & Animal Mycology (ISHAM) Conference, Amsterdam NL, The plant defensin HXP124 has the potential to be a new safe and effective topical treatment for onychomycosis (pdf)


Bleackley MR, Payne JAE, Hayes BME, Durek T, Craik DJ, Shafee TMA, van der Weerden NL, Anderson MA., Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumour cell killing and an enhanced antifungal variant., Antimicrobial Agents and Chemotherapy., (2016)

POSTER: Presented at ASM Microbe 2016, Boston MA, HXP124, a Plant Defensin, Represents a Novel Antifungal Therapeutic (pdf)

POSTER: Presented at ASM Microbe 2016, Boston MA, HXP124 as a novel treatment for onychomycosis (pdf)

POSTER: Presented at ASM Microbe 2016, Boston MA, Use of the Non-Essential Yeast Deletion Collection to Define the Antifungal Mechanisms of Plant Defensins


Hayes BM, Bleackley MR, Wiltshire JL, Anderson MA, Traven A, van der Weerden NL., Identification and mechanism of action of the plant defensin NaD1 as a new member of the antifungal drug arsenal against Candida albicans., Antimicrob Agents Chemother. 2013


van der Weerden NL, Hancock RE, Anderson MA., Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall-dependent process., J Biol Chem. 2010


van der Weerden NL, Lay FT, Anderson MA., The plant defensin, NaD1, enters the cytoplasm of Fusarium oxysporum hyphae., J Biol Chem. 2008