Peer Reviewed Papers

Hexima researchers pride themselves on publishing quality, cutting-edge science in high-impact, peer-reviewed journals.


Jackson A, Gilding E K, Shafee T, Harris K S, Kaas Q, Poon S, Yap K, Jia H, Guarino R, Chan L Y, Durek T, Anderson M A & Craik D J, Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases., Nat. Comm. (2018)

Hayes B, Bleackley M, Anderson MA, van der Weerden N, The plant defensin NaD1 enters the cytoplasm of Candida albicans via endocytosis., J Fungi. (2018)

Parisi K, Shafee TMA, Quimbar P, van der Weerden NL, Bleackley MR, Anderson MA., The evolution, function and mechanisms of action for plant defensins., Seminars in Cell and Developmental Biology (In Press) (2018)


Poon S, Harris KS, Jackson MA, McCorkelle OC, Gilding EK, Durek T, van der Weerden NL, Craik DJ, Anderson MA., Co-expression of a cyclising asparaginyl endopeptidase enables efficient production of cyclic peptides in planta., J Expt Bot. (2017)

Bleackley MR, Dawson CS, McKenna JA, Quimbar P, Hayes BME, van der Weerden NL, Anderson MA., Synergistic activity between two antifungal proteins, the plant defensin NaD1 and the bovine pancreatic trypsin inhibitor., ASM mSphere00390-17. (2017)


Shafee TMA, Lay FT, Phan TK, Anderson MA, Hulett MD., Convergent evolution of defensin sequence and structure., Cellular and Molecular Life Sciences. (2016)

Bleackley MR, Payne JAE, Hayes BME, Durek T, Craik DJ, Shafee TMA, van der Weerden NL, Anderson MA., Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumour cell killing and an enhanced antifungal variant., Antimicrobial Agents and Chemotherapy., (2016)

Shafee TMA, Lay FT, Hulett MD, Anderson MA., The defensins consist of two independent, convergent protein superfamilies., Molecular Biology and Evolution. (2016)

Payne JAE, Bleackley MR, Lee TH, Shafee TMA, Poon IKH, Hulett MD, Aguilar MI, van der Weerden NL, Anderson MA., The plant defensin NaD1 introduces membrane disorder through a specific interaction with the lipid, phosphatidylinositol 4,5 bisphosphate., Biochim Biophys Acta. (Bimembranes). (2016)

Shafee TMA, Robinson AJ, van der Weerden N, Anderson MA., Structural homology guided alignment of cysteine rich proteins., Springer Plus. (2016)


Harris KS, Durek T, Kaas Q, Poth AG, Gilding EK, Conlan BF, Saska I, Daly NL, van der Weerden NL, Craik DJ, Anderson MA., A recombinantly expressed, functional asparaginyl endopeptidase preferentially processes linear peptides to backbone cyclised products., Nat. Comm. (2015)

Lowe R, McCorkelle O, Bleackley M, Collins C, Faou P, Mathivanan S, Anderson MA., Extracellular proteases of the cereal pathogen Fusarium graminearum., Frontiers in Plant Science. (2015)


Gaspar, YM, McKenna, JA, McGinness, BS, Hinch, J, Poon, S, Connelly, AA, Anderson, MA and Heath, RL., Field resistance to Fusarium oxysporum and Verticillium dahliae in transgenic cotton expressing the plant defensin NaD1., J Exp Botany 65: 1541–1550. 2014

Bleackley MR, Hayes BM, Parisi K, Saiyed T, Traven A, Potter ID, van der Weerden NL, Anderson MA., Bovine pancreatic trypsin inhibitor is a new antifungal peptide that inhibits cellular magnesium uptake., Mol Microbiol. 2014

Poon IK, Baxter AA, Lay FT, Mills GD, Adda CG, Payne JA, Phan TK, Ryan GF, White JA, Veneer PK, van der Weerden NL, Anderson MA, Kvansakul M, Hulett MD., Phosphoinositide-mediated oligomerization of a defensin induces cell lysis., Elife. 2014

Bleackley MR, Wiltshire JL, Perrine-Walker F, Vasa S, Burns RL, van der Weerden NL, Anderson MA., Agp2p, the plasma membrane transregulator of polyamine uptake, regulates the antifungal activities of the plant defensin NaD1 and other cationic peptides., Antimicrob Agents Chemother. 2014

Hayes BM, Anderson MA, Traven A, van der Weerden NL, Bleackley MR., Activation of stress signalling pathways enhances tolerance of fungi to chemical fungicides and antifungal proteins., Cell Mol Life Sci. 2014

Lay FT, Poon S, McKenna JA, Connelly AA, Barbeta BL, McGinness BS, Fox JL, Daly NL, Craik DJ, Heath RL, Anderson MA., The C-terminal propeptide of a plant defensin confers cytoprotective and subcellular targeting functions., BMC Plant Biol. 2014

Dracatos PM, van der Weerden NL, Carroll KT, Johnson ED, Plummer KM, Anderson MA., Inhibition of cereal rust fungi by both class I and II defensins derived from the flowers of Nicotiana alata., Mol Plant Pathol. 2014


Hayes BM, Bleackley MR, Wiltshire JL, Anderson MA, Traven A, van der Weerden NL., Identification and mechanism of action of the plant defensin NaD1 as a new member of the antifungal drug arsenal against Candida albicans., Antimicrob Agents Chemother. 2013

Garvey M, Meehan S, Gras SL, Schirra HJ, Craik DJ, Van der Weerden NL, Anderson MA, Gerrard JA, Carver JA., A radish seed antifungal peptide with a high amyloid fibril-forming propensity., Biochim Biophys Acta. 2013

van der Weerden NL, Bleackley MR, Anderson MA., Properties and mechanisms of action of naturally occurring antifungal peptides., Cell Mol Life Sci. 2013

Stevens JA, Dunse KM, Guarino RF, Barbeta BL, Evans SC, West JA, Anderson MA., The impact of ingested potato type II inhibitors on the production of the major serine proteases in the gut of Helicoverpa armigera., Insect Biochem Mol Biol. 2013


Conlan BF, Colgrave ML, Gillon AD, Guarino R, Craik DJ, Anderson MA., Insights into processing and cyclization events associated with biosynthesis of the cyclic Peptide kalata B1., J Biol Chem. 2012

Lay FT, Mills GD, Poon IK, Cowieson NP, Kirby N, Baxter AA, van der Weerden NL, Dogovski C, Perugini MA, Anderson MA, Kvansakul M, Hulett MD., Dimerization of plant defensin NaD1 enhances its antifungal activity., J Biol Chem. 2012


Conlan BF, Anderson MA., Circular micro-proteins and mechanisms of cyclization., Curr Pharm Des. 2011

Conlan BF, Gillon AD, Barbeta BL, Anderson MA., Subcellular targeting and biosynthesis of cyclotides in plant cells., Am J Bot. 2011


van der Weerden NL, Hancock RE, Anderson MA., Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall-dependent process., J Biol Chem. 2010

Dunse KM, Kaas Q, Guarino RF, Barton PA, Craik DJ, Anderson MA., Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitor., Proc Natl Acad Sci. 2010

Dunse KM, Stevens JA, Lay FT, Gaspar YM, Heath RL, Anderson MA., Coexpression of potato type I and II proteinase inhibitors gives cotton plants protection against insect damage in the field., Proc Natl Acad Sci. 2010

Conlan BF, Gillon AD, Craik DJ, Anderson MA., Circular proteins and mechanisms of cyclization., Biopolymers. 2010


Schirra HJ, Anderson MA, Craik DJ., Structural refinement of insecticidal plant proteinase inhibitors from Nicotiana alata., Protein Pept Lett. 2008

van der Weerden NL, Lay FT, Anderson MA., The plant defensin, NaD1, enters the cytoplasm of Fusarium oxysporum hyphae., J Biol Chem. 2008

Barbeta BL, Marshall AT, Gillon AD, Craik DJ, Anderson MA., Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae., Proc Natl Acad Sci. 2008

Gillon AD, Saska I, Jennings CV, Guarino RF, Craik DJ, Anderson MA., Biosynthesis of circular proteins in plants., Plant J. 2008

Jennings CV, Rosengren KJ, Daly NL, Plan M, Stevens J, Scanlon MJ, Waine C, Norman DG, Anderson MA, Craik DJ., Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?Biochemistry. 2005

Lay FT, Anderson MA., Defensins–components of the innate immune system in plants., Curr Protein Pept Sci. 2005

Janssen BJ, Schirra HJ, Lay FT, Anderson MA, Craik DJ., Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds., Biochemistry. 2003

Anderson MA, Van Heeswijck R, West J, Bateman K, Lee M, Christeller JT, McDonald G, Heath RL., Proteinase inhibitors from Nicotiana alata enhance plant resistance to insect pests., J Insect Physiol. 1997

Lay FT, Brugliera F, Anderson MA., Isolation and properties of floral defensins from ornamental tobacco and petunia., Plant Physiol. 2003

Lay FT, Schirra HJ, Scanlon MJ, Anderson MA, Craik DJ., The three-dimensional solution structure of NaD1, a new floral defensin from Nicotiana alata and its application to a homology model of the crop defense protein alfAFP., J Mol Biol. 2003

Jennings C, West J, Waine C, Craik D, Anderson M., Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis., Proc Natl Acad Sci. 2001

Nielsen KJ, Hill JM, Anderson MA, Craik DJ., Synthesis and structure determination by NMR of a putative vacuolar targeting peptide and model of a proteinase inhibitor from Nicotiana alata., Biochemistry. 1996